How the United States Beat the Variants, for Now


On Dec. 29, a National Guardsman in Colorado became the first known case in the United States of a contagious new variant of the coronavirus.

The news was unsettling. The variant, called B.1.1.7, had roiled Britain, was beginning to surge in Europe and threatened to do the same in the United States. And although scientists didn’t know it yet, other mutants were also cropping up around the country. They included variants that had devastated South Africa and Brazil and that seemed to be able to sidestep the immune system, as well as others homegrown in California, Oregon and New York.

This mélange of variants could not have come at a worse time. The nation was at the start of a post-holiday surge of cases that would dwarf all previous waves. And the distribution of powerful vaccines made by Moderna and Pfizer-BioNTech was botched by chaos and miscommunication. Scientists warned that the variants — and B.1.1.7 in particular — might lead to a fourth wave, and that the already strained health care system might buckle.

That didn’t happen. B.1.1.7 did become the predominant version of the virus in the United States, now accounting for nearly three-quarters of all cases. But the surge experts had feared ended up a mere blip in most of the country. The nationwide total of daily new cases began falling in April and has now dropped more than 85 percent from the horrific highs of January.

“It’s pretty humbling,” said Kristian Andersen, a virologist at Scripps Research in La Jolla, Calif. “We could actually do a lot better than I had expected.”

Dr. Andersen and other virus watchers still see variants as a potential source of trouble in the months to come — particularly one that has battered Brazil and is growing rapidly in 17 U.S. states. But they are also taking stock of the past few months to better understand how the nation dodged the variant threat.

Experts point to a combination of factors — masks, social distancing and other restrictions, and perhaps a seasonal wane of infections — that bought crucial time for tens of millions of Americans to get vaccinated. They also credit a good dose of serendipity, as B.1.1.7, unlike some of its competitors, is powerless against the vaccines.

“I think we got lucky, to be honest,” said Nathan Grubaugh, an epidemiologist at Yale University. “We’re being rescued by the vaccine.”

After B.1.1.7 emerged at the end of December, new variants with combinations of troubling mutations came to light. Scientists fretted about how the competition between the variants might play out.

In January, researchers in California discovered a variant with 10 mutations that was growing more common there and had drifted into other states. Laboratory experiments suggested that the variant could dodge an antibody treatment that had worked well against previous forms of the virus, and that it was perhaps also more contagious.

In the months that have followed, the United States has drastically improved its surveillance of how the variants mutate. Last week more than 28,800 virus genomes, almost 10 percent of all positive test cases, were uploaded to an international online database called GISAID. That clearer picture has enabled scientists to watch how the mutants compete.

The California variant turned out to be a weak competitor, and its numbers dropped sharply in February and March. It is still prevalent in parts of Northern California, but it has virtually disappeared from southern parts of the state and never found a foothold elsewhere in the country. By April 24, it accounted for just 3.2 percent of all virus samples tested in the country, as B.1.1.7 soared to 66 percent.

“B.1.1.7 went in for the knockout, and it’s like, ‘Bye bye, California variant,’” Dr. Andersen said.

On the other side of the country, researchers reported in February that a variant called B.1.526 was spreading quickly in New York and appeared to be a formidable adversary for B.1.1.7. By February, each of those variants had grown to about 35 percent of the samples collected by Dr. Grubaugh’s lab in Connecticut. But B.1.1.7 came out on top.

In fact, B.1.1.7 seems to have the edge over nearly every variant identified so far. At a congressional hearing on Tuesday, Dr. Rochelle P. Walensky, the director of the Centers for Disease Control and Prevention, said B.1.1.7 made up 72 percent of cases in the country.

“We’re really seeing B.1.1.7 pushing out other variants decisively,” said Emma Hodcroft, an epidemiologist at the University of Bern.

The variants identified in California and New York turned out to be only moderately more contagious than older versions of the virus, and much of their initial success may have been luck. The overall boom in cases last fall amplified what might otherwise have gone undetected.

It’s unclear what gives B.1.1.7 an edge over the others. “Is it the greatest of all the variants? It’s just really hard to say right now,” said Angela Rasmussen, a virologist at the University of Saskatchewan’s Vaccine and Infectious Disease Organization. “We need more research to figure out more about what all of these combinations of mutations are doing.” Some answers may come from California, where researchers are staging a head-to-head competition in a lab, injecting mice with a cocktail of B.1.1.7 and six other variants.

“The idea is to see which one will win out,” said Dr. Charles Chiu, a virologist at the University of California, San Francisco, who was the first scientist to discover the California variant.

In Michigan, one of the few states that saw the predicted surge in cases this spring, B.1.1.7 found a hook in younger people who were returning to schools and playing contact sports.

“Because it’s more transmissible, the virus finds cracks in behavior that normally wouldn’t have been as much of a problem,” said Emily Martin, an epidemiologist at the University of Michigan.



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